What is the primary indicator of liver disease in blood tests?

The primary indicator of liver disease in blood tests is the elevation of liver enzymes, such as AST (aspartate aminotransferase) and ALP (alkaline phosphatase). These enzymes are typically released into the bloodstream when liver cells are damaged or inflamed, reflecting liver dysfunction. Elevated levels indicate that there is a disturbance in liver function, which can be due to various conditions, including hepatitis, liver cirrhosis, or toxic liver damage.

While the presence of bilirubin is also significant, as bilirubin levels can increase when the liver is unable to conjugate or excrete it properly, elevated liver enzymes are considered more direct indicators of liver cell injury and overall liver health. Decreased white blood cell count and high levels of cholesterol can be observed in various conditions but are not specific markers for liver disease. Thus, the elevation of liver enzymes is the most reliable indicator when assessing liver health through blood tests.